Leukotriene C4 modulation of muscarinic K+ current activation in bullfrog atrial myocytes.
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منابع مشابه
Leukotriene C4 modulation of muscarinic K+ current activation in bullfrog atrial myocytes
The effects of leukotriene C4 (LTC4) on activation of muscarinic acetylcholine receptor (mAChR)-stimulated, inwardly rectifying K+ current (IK[ACh]) were examined in single bullfrog atrial myocytes using the whole-cell patch clamp technique. LTC4 produced a reversible, concentration-dependent increase in steady-state, guanosine-gamma-thiotriphosphate (GTP gamma S)-activated IK[ACh], with a K0.5...
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Platelet-activating factor (PAF), a potent signaling lipid implicated as a mediator of pathological responses, has both negative chronotropic and inotropic effects on the heart, although the mechanism(s) involved is not well defined. Because activation of the muscarinic acetylcholine-activated K' current (IK(ACh)) also produces a negative chronotropic and inotropic response in myocardium, this ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1993
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.102.1.125